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The IVF Fertility Blog

How to Grade Embryo Quality Through PGD Technology

Embryo quality is one of the key factors in the success of an IVF cycle. In order to maximize the rate of IVF success, the Preimplantation Genetic Diagnosis (PGD) specialists at New Hope Fertility NYC only select and transfer the highest quality embryos developing in vitro. Determining quality requires embryo grading - a process of evaluating and assigning a grade to embryos. 

PGD and the Embryo Grading Process

There are multiple scales for grading embryos. One of the most widely used is to evaluate embryos on their third day of development.

On Day No. 3 in vitro, the following key factors are analyzed:   pgd.jpg

  • Number of Cells - As an embryo progresses, the number of cells it contains will increase. On Day No. 3, quality embryos will contain between 7 and 10 cells. 
  • Cell Regularity - For a quality grade, the cells within an embryo should be similar in size. Cells that are dramatically different in size may be indicative of an abnormality. 
  • Fragmentation - Fragmentation occurs when parts of a cell within an embryo break away. While it is ideal to have little to no fragmentation, some fragmentation is normal. If more than 25 percent of the embryo’s cells are fragmented, the embryo will likely have difficulty implanting. 
  • Number of Nuclei  - An embryo should have one nucleus. Embryos with more than one nucleus are more likely to have chromosomal issues.  

Embryo Grading Scale 

There are a number of scales for identifying embryo quality.  An example of one such scale is below. 

  • Grade Level 1 - Good cell regularity, no fragmentation 
  • Grade Level 2 - Good cell regularity, little fragmentation 
  • Grade Level 2.5 - Good cell regularity, some fragmentation 
  • Grade Level 3 - Poor cell regularity, no or little fragmentation 
  • Grade Level 4 - Poor cell regularity, heavy fragmentation 

The lower the grade level, the higher quality the embryo. Embryos at high grade levels are least likely to implant and to result in a live birth. Embryologists and fertility doctors use the grading scale to determine which embryos should be transferred.

PGD Technology in Conjunction With IVF

For more information about how PGD technology can help you achieve a successful pregnancy through IVF, contact New Hope Fertility. It is important to work with a fertility care team who understands which IVF treatment protocol is best for you as an individual. Customized IVF care at New Hope Fertility NYC offers the highest success rates and best overall patient satisfaction.

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