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The IVF Fertility Blog

How Does Synarel Nasal Spray Work

Synarel nasal spray has a number of medical uses including as a fertility drug.  During IVF treatment, Synarel nasal spray used as a trigger, enabling the fertility care team to time ovulation for egg retrieval.

How does Synarel work?

When taken, Synarel causes a surge in the amount of LH, or luteinizing hormone, in a woman’s body.  A sharp rise in the amount of LH in a woman’s body both triggers ovulation and the development of the corpus luteum which helps to prepare the body for pregnancy.  Additionally, Synarel helps to mature the follicles that release the eggs.


How does Synarel aid IVF treatment?

Once Synarel is administered, a woman will typically ovulate in 36 to 48 hours. This timeframe allows the fertility care team to time and coordinate the egg retrieval to occur just prior to ovulation.  This produces eggs that are mature and a ready for fertilization.

Are there side effects when Synarel is used?

As with many medications used during fertility treatment, Synarel has potential side effects.  Not all women have the same reaction to the medication.  Some women will have little to no side effects, other women may experience several.  Reported side effects from using Synarel include:

  • Hot flashes
  • Headaches
  • Muscle pain
  • Mood swings
  • Runny nose
  • Nasal irritation

Why is Synarel preferred over other triggers?

Some fertility centers use other medication that contains hCG to trigger ovulation.  While these medications are effective to cause ovulation they have a number of undesirable affects.  Due to its potency, hCG lasts longer in the body than LH.  Additionally, hCG stimulates both the mature follicles and small follicles.  Those small follicles can in turn become cysts.  Synarel is strong enough to trigger ovulation, but does not stay in the body long enough to stimulate the smaller follicles.  This can eliminate the need to wait between cycles and can be beneficial to women who have a low ovarian reserve.

For additional information on the use of Synarel nasal spray to trigger ovulation, contact the fertility experts at New Hope Fertility Center today.  Please click the link below to enter your information and New Hope will contact you, or simply call 212-517-7676. Thank You.

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