Because IVF bypasses many common medical causes of infertility, it is the preferred treatment option for patients who have failed multiple IUIs. After thorough diagnostic testing has been performed to determine that your infertility is not structural, we will recommend the most promising treatment option. IUI – Intrauterine Insemination or artificial insemination – is often recommended as a first treatment option for unexplained infertility because it is the least invasive and most affordable. IUI boosts a woman’s pregnancy chances between 10 and 20 percent. Typically, IVF is not recommended until three to four IUI cycles have failed before IVF.