Genetic screening of embryos in vitro has increased yearly IVF pregnancy success rates at New Hope Fertility Center by up to 30 percent. By checking out this data, you can get an idea of your average chance of pregnancy success through IVF. Look: PGS/NGS is recommended because this technology is proven to increase a patient’s average chances of pregnancy success. Why does this matter? All IVF success rates vary per the context of patient and treatment protocol characteristics. Bonus: PGS/NGS identifies the gender of your embryos so that you can plan and balance the sexes of your children.
IVF Candidates for Genetic Screening
We typically recommend genetic screening in conjunction with IVF for patients meeting one or more of the following categories.
- Age 35 and older
- History of previous pregnancies
- History of miscarriages
- History of failed IVF cycles – fresh and frozen transfers
When a woman reaches an advanced maternal age – over 35 – her chances for conceiving a baby having chromosomal abnormalities increase.
Why is this important? Low quality embryos:
- Reduce pregnancy success rates
- Increase miscarriage rates
- Increase chances for birth defects
There are a number of genetic conditions that can adversely alter the course of life – both for baby and parents. PGS and NGS can be performed on each embryo developing in vitro – in the lab.
PGS/NGS is used to identify the most suitable and healthiest embryo(s) to transfer. This genetic screening technology detects chromosomal deficiencies in embryos – aneuploidy – an extra or missing chromosome.
Preimplantation Genetic Screening (PGS) in vitro reduces your chances of having a baby afflicted with developmental disabilities due to chromosomal abnormalities. The vast majority of embryo implantation failures and miscarriages are due to abnormal chromosomes.
Next Generation Sequencing (NGS) is on the horizon of replacing PGS because it is a new and innovative genetic testing technology used to perform chromosomal testing in vitro.
NGS is used for comprehensive testing of embryos at a lower cost and error rate than PGS.
PGS and NGS
PGS/NGS is the observance and evaluation of the health of an embryo prior to transfer.
This genetic testing technology virtually eliminates the chance of transferring an embryo with abnormal chromosomes to the mother’s uterus. PGS/NGS analyzes the health of a single cell from a developing embryo in vitro.
This cell can identify the presence of too many or too few chromosomes making up the embryo. If an abnormal chromosome count is identified, the embryo is not transferred.
Transferring only healthy embryos significantly increases the chances of a successful IVF pregnancy and birth.
Benefits of PGS/NGS
Cutting-edge embryo biopsy technology has been proven to increase IVF pregnancy success rates. This remarkable Assisted Reproductive Technology (ART) in conjunction with IVF identifies genetic and chromosomal abnormalities in embryos prior to transfer.
Only high quality embryos are transferred during a fresh IVF cycle or cryopreserved.
- Reduced number of failed embryo implantations
- Reduced number of miscarriages
- Reduced number of fresh IVF cycles
- Increased number of Frozen Embryo Transfer (FET) cycles
- Increased pregnancy rates
- Increase live birth rates
- Gender identification and selection of embryos
PGS/NGS takes place in conjunction with IVF in a controlled laboratory setting. Approximately five (5) days – blastocyst stage – after fertilization of the patient’s eggs in vitro, a single cell is removed from each of the embryos developing.
- A single cell is removed from the embryo by a highly skilled embryologist using a laser and a microscopic glass needle
- The single cell’s genetic makeup is analyzed by the embryologist under a microscope
- A decision is made as to the quality of each of the individual embryos
- Only high quality embryos are used in completion of a fresh IVF cycle
- Only high quality embryos are cryopreserved for future FETs
World Renowned PGS/NGS Fertility Specialists
To schedule your initial consultation with our PGS/NGS fertility specialists, click the icon below – or – call 917.525.5496.