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The IVF Fertility Blog

POF DISCUSSION SERIES: PREPARATION FOR IN-VITRO FERTILIZATION

Today, we would like to continue our discussion on Primary Ovary Insufficiency (POF) by informing you on how we prepare patients with low ovarian reserve for In-Vitro Fertilization. POF-3

If a patient’s FSH is higher than 25, we will start birth control pills for 7-10 days.  When the FSH reduces to below 6-8, we will switch to oral estrogen (2mg per day), for 10 days.  During this period of time, we will periodically measure the number of follicles in the patient’s ovary.   Once 2-3 follicles start to emerge, we will start a stimulation protocol.  

A stimulation protocol is typically a combination of Clomid pills with an injection of a Follitropin, usually either Follistim or Gonal-F, at a dose of 75 units per day for 7-10 days.  Please note it’s very important to keep the FSH below 6 to allow the quality of the egg to be assured.  This is a common protocol we use at New Hope with patients whose FSH is above 25. However, New Hope provides individualized care and treatment plans for each patient based on their specific medical history.

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