Today’s Assisted Reproductive Technology (ART) helps to increase the healthy birth rates of babies through genetic testing. This is because only the healthiest embryos are transferred for implantation during a fresh IVF cycle and/or Frozen Embryo Transfer (FET). Genetic testing helps to reduce the number of cycles required to achieve a healthy pregnancy.
PGS – Preimplantation Genetic Diagnosis
PGS is the testing of an embryo’s overall chromosomal normalcy prior to being transferred to the patient’s uterus in conjunction with IVF. PGS identifies the most suitable and healthiest embryo to transfer by detecting chromosomal deficiencies – aneuploidy – an extra or missing chromosome.
PGS Increases Pregnancy Success Rates
New studies show that PGS dramatically increases a woman’s chance of conception. This is because her doctor has the skill and expertise to identify the most suitable and healthiest embryo(s) to transfer. At New Hope Fertility NYC, embryo biopsy and screening can increase a patient’s chance of a successful pregnancy by up to 30 percent.
PGD – Preimplantation Genetic Diagnosis
PGS differs from Preimplantation Genetic Diagnosis (PGD) because the procedure does not diagnose an inherited genetic defect in the embryo. PGS searches for aneuploidy – extra or missing chromosomes.
In comparison, PGD diagnoses genetic defects such as:
- Cystic Fibrosis
- Tay Saches
- Sickle Cell Anemia
Candidates for Preimplantation Genetic Screening (PGS)
Because advanced maternal age (over 35) adversely affects the quality of a woman’s eggs – oocytes – resulting in chromosomal abnormalities, New Hope Fertility NYC recommends PGS in conjunction with IVF to patients over the age of 35.
In an ideal world, our doctors would recommend PGS for every IVF patient. The pros of PGS are that you learn a lot about the health of your embryo and then make completely informed decisions. The cons of PGS are cost and a 1.5 percent error rate. PGS finding are not infallible. Patients are in good hands at New Hope Fertility NYC.
Other Candidates for PGS
- Women having a history of recurrent miscarriages (2 or more)
- Women having failed IVF cycles
- Gender Selection – Family Balancing
PGS Detects Low Quality Embryos
By extracting a cell from an embryo and analyzing it, poor quality embryos are detected. Biopsy of this cell will not damage the embryo.
Low quality embryos result in:
- Low pregnancy success rates
- High miscarriage rates
- High chance for birth defects
Next Generation Sequencing (NGS)
NGS – Next Generation Sequencing – is a new method of PGS. NGS is the latest genetic screening test for primary candidates undergoing IVF. NGS is used for comprehensive chromosome testing of embryos created through IVF. NGS is on the horizon to replacing PGS because of the procedure’s lower cost and reduced errors.
NGS allows embryologists to screen for defects on the chromosomal level with higher accuracy and more detail than ever before. PGS results are comprehensive and a higher resolution than any other genetic testing method because it detects more translocations.
NGS may be run as a standalone test – or in conjunction with PGS – at a faster completion rate. NGS also detects mosaicism – when the embryo’s cells exhibit different chromosomal content.
Primary Benefits of NGS
- Reduce the number of miscarriages
- Reduce the number of IVF cycles
- Reduce the risk of multiple pregnancy with a single embryo transfer
- Increase ongoing pregnancy rates
- Increase live births
Importance of NGS
As a woman reaches an advanced maternal age (35 and older), there is a greater chance that her low quality eggs will create chromosomally abnormal embryos. The primary goal of NGS is to transfer embryos that have been found to have a normal chromosomal number – euploid.
Embryo morphology – how the embryo looks – alone as a means of selection for transfer is not the best tool. It is best to couple PGS with NGS to eliminate the chance of good looking embryos being abnormal.
World Renowned IVF Experts
It is important to work with a fertility care team having the experience required to design a customized IVF treatment plan meeting your specific personal needs. To schedule your initial consultation with one of the world renowned fertility specialists at New Hope Fertility NYC, click the icon below – or – call 917.525.5496.