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The IVF Fertility Blog

What are the Most Common Fertility Drug Problems?

Fertility medication can play a large role in fertility care. Unfortunately, many fertility medications have side effects that can make the process uncomfortable. Understanding the common fertility drug problems will better prepare you for what you can expect during treatment.

Common fertility drug problems as identified by patients include:doctors-for-pregnancy

Birth Control Pills

Birth control pills are commonly used to regulate or synchronize your cycle.  The pills work by blocking your body’s natural production of the hormones FSH and LH. This reaction generally prevents your body from producing and releasing an egg. Side effects include:

  • Headaches
  • Nausea
  • Blotting
  • Tenderness of the breasts


Clomid is among the most commonly prescribed fertility medications. Clomid works by stimulating your body to produce more FSH and maintain the LH. These hormones both promote the maturation of eggs and decrease the likelihood that eggs will be released before they have reached the appropriate maturity level.  Women have reported:

  • Pelvic discomfort
  • Hot flashes
  • Headache
  • Vomiting
  • Blurred vision


Estrace encourages your body’s uterine lining growth to ensure your uterus is ready to support a growing fetus. Common fertility drug problems reported with Estrace include:

  • Appetite loss
  • Vomiting
  • Chest pain
  • Swelling of the hands and feet


Femara works by preventing your body from producing estrogen. In response, your body produces excess FSH which stimulates your body to produce eggs and ovulate. Some side effects include:

  • Hot flashes
  • Weight gain
  • Weakness
  • Fatigue
  • Discomfort throughout your body

Antagon / Cetrotide

These medications are comprised of protein. The medication works by reducing the levels of certain hormones in your body in order to suppress or delay ovulation. Patients who have taken this medication have reported side effects including:

  • Headaches
  • Nausea
  • Abdominal swelling
  • Pain or discomfort at the injection site
  • Cramping

Novarel / Pregnyl / Ovidrel

These injectable medications containing hCG which allows your doctors to correctly time your ovulation. The medication mimics your body’s natural way and timing for ovulation. This timing is important for both egg harvesting and timed intercourse. Some women have reported the following side effects:

  • Mood swings
  • Headaches
  • Breast tenderness
  • Mild swelling


This over the counter medication is commonly used to reduce pain. Additionally, ibuprofen is an anti-inflammatory. When you take ibuprofen you are less likely to have a follicle rupture prematurely. Some of the experienced side effects include:

  • Heartburn
  • Upset stomach
  • Bloating
  • Drowsiness 

Speak with one of our fertility care specialists to learn more about common fertility drug problems. Please click the link below to enter your information and New Hope will contact you, or simply call 212-517-7676. Thank You.

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